INJURY AND RECOVERY IN NEUTRON-IRRADIATED ANIMALS 



the giant amoeba, Pelomyxa illinoisensis, when unirradiated protoplasm was 

 micro-injected into a neutron-irradiated cell. Further studies in recovery 

 after fission neutron irradiation are now in progress. 



T/ie authors ivis/i to express their sincere appreciation to Richard R. Barhorst and 

 Nicholas Bink for their excellent technical assistance in this work. We also wish to 

 thank At lee Tracy and Jane Glaser for aid in the photographic work and Dr. Robert 

 Straube for advice in the cysteine experiment. These individuals are all members of 

 the Biological and Medical Research Division of Argonne National Laboratory. 



REFERENCES 



^Clark, J. W., Jordan, D. L. and Vogel, H. H., Jr. Amer.J. Roentgenol. 77 (1957) 



524 

 2\'oGEL, H. H. Jr., Blomgren, R. A. and Bohlin, N. J. G. Nucleonics 11, No. 3 



(1953) 28 

 ^ZiRKLE, R. E., Raper, J. R., Riley, E. F., Jr. and Stapleton, G. E. U.S. Atomic 



Energy Commission Report AECD-2328, 1945 

 « Vogel, H. H., Jr., Clark. J. W. and Jordan, D. L. Radiology 68 (1957) 386 

 ^Vogel, H. H., Jr., Clark, J. W. and Jordan, D. L. Radiation Res. 6 (1957) 460 

 6LESHER, S. and Vogel, H. H., Jr. Radiation Res. 9 (1958) 560 

 7 Hammond, C, Vogel, H. H., Jr., Clark, J. W., Cooper, D. B. and Miller, C. P. 



Radiation Res. 2 (1955) 354 

 SPATT, H. M., Clark, J. W. and Vogel, H. H., Jr. Proc. Soc. exp. Biol., N.Y. 84 



(1953) 189 

 9 Vogel, H. H., Jr., Clark, J. W., Hammond, C. W., Cooper, D. B. and Miller, 



C. P. Proc. Soc. exp. Biol., N.Y. 87 (1954) 114 

 1" Vogel, H. H., Jr. publication of the Biological and Medical Research Division, Argonne 



National Laboratory (1959) — in the press 

 "Daniels, E. W. and Vogel, H. H., Jr. Radiation Res. (1959)— in the press 



DISCUSSION 



Professor White: From the fact that there were no deaths from this second immuno- 

 logical reaction, would you conclude that the fission neutrons were more effective in 

 knocking out the normal immunological mechanism of the animal than X irradiation, 

 for example ? 



Dr. Vogel: That is a very interesting point, and I am not sure of it. There is a 

 tendency, I think, from these data, to conclude that neutrons may be more effective. 

 The only reason I say that, is, that after similar y irradiation, one does get some 

 secondary homologous deaths, and so far I have six neutron experiments running and 

 the animals are sdll there and we have not had a significant secondary death. I think 

 it is a very important point to follow up. 



Dr. Loutit: If I can go further — you showed some results with C57 black mice which 

 were given combined treatment. Now, the bone marrow for those C57 blacks, is 

 that isologous C57? 

 Dr. Vogel: Yes. 



Dr. Loutit: But even so, even with that isologous marrow, the deaths in this case 

 were substantial for one reason or another? 



Dr. Vogel: That is so. As you know. Dr. Loutit, these experiments do vary from 

 time to time, with technique and other factors. But I was interested by the fact that 

 the results from C57 black mice were not as good as those from the CF No. I strain. 



234 



