INFLUENCE OF OXYCiEN ()\ RADH )-SI..\SI 1 I\ ITY OF CELLS AM) IISSUES 



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found not to alter the induced dominant mutation rate. The induction of 

 dominant mutations in Drosophila sperm shows only a small oxygen depen- 

 dence, but in this case there is independent evidence that mature Drosophila 

 sperm normally exist at low oxygen tensions. 



Both from the practical standpoint and in relation to the understanding 

 of the role of oxygen in radiobiology, a knowledge of the quantitative 

 dependence of radio-sensitivity on available oxygen is of great importance. 

 Since we have no direct measure of oxygen tension within the cell, the best 

 we can do is to correlate sensitivity with the concentration of oxygen in the 

 immediate environment of the cell. Howard-Flanders and Alper'* were the 

 first to obtain a precise evaluation of this relation between oxygen sensitivity 

 and oxygen concentration. They worked with bacteria and yeast which 



154 



