I. D. THOMAS, T. H. ODDIE, AND F. F. RUNDLE 



Uptake rate at lowest observed point 

 Hyperthyroid range: 5 patients 

 Euthyroid range: 4 patients 



Uptake rate at 28 days 



Hyperthyroid range: 8 patients 

 Euthyroid range: 1 patient 



Not requiring further therapy (7 patients) 

 Time of lowest observed uptake 



13 days: 3 patients 



28 days: 4 patients 



Uptake rate at lowest observed point 



Hyperthyroid range: 1 patient 



Euthyroid range: 4 patients 



Hypothyroid range: 2 patients 



Uptake rate at 28 days 



Hyperthyroid range: 1 patient 



Euthyroid range: 4 patients 



Hypothyroid lange: 2 patients 



DISCUSSION OF RESULTS 



The results suggest that the mode of response in the first 28 days may be of 

 value in determining whether the patient will obtain a satisfactory therapeutic 

 response to the dose he has received. 



Of the nine patients who required retreatment the uptake rate at 28 days 

 was rising and was in the hyperthyroid range in eight patients. In only one 

 patient was there no clear indication from the uptake studies that retreatment 

 would be necessary. Of the seven patients who did not require retreatment 

 only one had a high uptake at 28 days. 



The number of patients so far studied is small; wider experience may lead 

 to different conclusions, but it appears reasonable to hope that observations 

 of the type described may enable a programme of therapy to be advanced by 

 at least one month. With therapy given at an earlier point on a rising slope, 

 the theoretically necessary dose is smaller and this offers a way of reducing 

 the radiation to which the patient is exposed. 



REFERENCES 



^Oddie, T. H., Meschan, I. and Wortham, J. /. din. Invest. 34 (1955) 106 

 ^Oddie, T. H., Rundle, F. F. and Meschan, I. Int. J. appl. Radiation 5 (1959) 77 

 ^Thomas, I. D., Oddie, T. H. and Rundle, F. F. Unpublished data 

 *Oddie, T. H., Thomas, I. D., Myhill, J. and Fitzsimons, E. To be published 



DISCUSSION 



Dr. Loutit: There was one other point that I picked up that you did not mention; 

 in the first group in the slide the doses were in the region of 10, 20, 40 millicuries; in 

 the second group they were all low doses of the order of 1 to 4 millicuries. Is there 

 any significance in these diflferences in doses of radioiodine ? 



17 245 



