64 p. C. KOLLER AND S. M. A. DOAK 



distortion in the proportion of particular cell types, and with the increase in the 

 number of the serial passage, the degree of distortion was accentuated and its 

 duration prolonged. The relationship of these changes to the incidence of 

 leul^aemia has yet to be evaluated. 



ACKNOWLEDGEMENTS 



This investigation has been supported by grants to the Chester Beatty 

 Eesearch Institute (Institute of Cancer Eesearch: Eoyal Cancer Hospital), 

 from the Medical Research Council, the British Empire Cancer Campaign, 

 the Anna Fuller Fund, and the National Cancer Institute of the National 

 Institutes of Health, U.S. Public Health Service. 



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