58 L. NEMETH 



(i) hepatic lesions, cliolangioma, atrojDliic testis, splenic lesions, giant 

 cells, plasma-cell metaplasia of lymph nodes, etc., in both the susceptible 

 and non-susceptible strains, 



(ii) metaplasia of the Bowmann capsule, pulmonary adenoma, fibro- 

 sarcoma at abdommal sites of injection, etc., in the non-susceptib]e strain 

 only. 



All experimental animals of both strains, except those treated with saline, 

 ceased to multiply and grew obese, particularly the males. 



The changes in the weekly counts of the white blood cells revealed 

 initially eosinophiha and lymphopenia after X-ray treatment and Degranol, 

 and leucocytosis after Mannitol-myleran; later, anaemia and increases in 

 the number of nuclear erythrocytes and young lymphoid elements followed 

 these three types of treatment. From these pre-haemoblastic changes it was 

 possible in some instances to predict imminent leukaemia. 



Whereas the three treatments differed in their early haematopoietic effect, 

 the late effect was invariably a lymphatic reaction. 



Thanks are due to B. Kellner, K. Lapis, and Margaret Dancshazy for 

 pathological studies. 



