CHOLESTEKOL CONCENTRATION IN ADRENAL GLANDS 227 



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DISCUSSION 



BACQ: The nero-endocrine factors are important both for acute reactions and for long- 

 term eflfects. One must not forget that the whole biochemistry of connective tissue is 

 controlled by the pituitary gland and the adrenal cortex. The extent to which the pitui- 

 tary is controlled by the CNS is an important factor also. It seems that the pituitary has 

 a certain amount of independent capacity to secrete its hormones. The fact that you have 

 taken out the hypophysis and grafted a foreign gland into the eye does not necessarily 

 mean that the graft is absolutely deprived of control from the CNS because we do know 

 that the control of the hypothalamus over the pituitary is mainly acliieved tlirough a 

 kind of neurohormone. It may weU be that, also in your case, the neurohormone goes into 

 the blood and affects the graft. It is kno^vn that the sensitivity of denervated tissue to its 

 chemical stimulus is very much increased, sometimes ten-fold or more. Dr. Martinovitch's 

 results seem to suggest that the hypothalamus is capable of secreting a substance which 

 goes into the blood and may affect heterotopic grafts. 



