Hi K. SUNDARAM 



deal of that got into the body and irradiated it before being lost in the urine and in the 

 faeces. So these animals were getting quite a large dose of whole-body radiation if they 

 were given half a mUlicurie or something like that. Further because it was in the food and 

 because the turn-over time of strontium is very rapid, they were, in fact given a set of 

 pulsed doses of whole-body radiation. The doses varied during the day so that it could 

 easily be that one could have a kind of leukaemogenic whole-body irradiation from 

 giving animals ^°Sv. 



CASABETT: There was ample opportunity for lymphatic tissue to be irradiated. In 

 answer to your question. Dr. Upton, there was ulceration either before or after tumour 

 development in these face tumours. As to the figures in the table, the survival time at the 

 high-dose level was generally much shorter than the average induction time for leuk- 

 aemia, following the treatment with strontium. I think, in these cases when one speaks 

 of increased incidence at the intermediate level and relative reduction at the high 

 level, we have consistently a picture where the survival time is too short for the observed 

 induction time of the tumours involved. At the lowest level apparently the dose is 

 insufficient to produce an increased incidence of mahgnancy. 



