NON-NEOPLASTIC LATE EFFECTS 185 



animals is increasing; I would like to direct special attention to its study in 

 pigs (Niissel and Schunk, 1961) and to the demonstration of radiation- 

 produced failure by chronic salt loading (Lamson et al., 1962). Whether the 

 decrease of resistance to cold stress in mice, caused by age as well as by 

 irradiation (Trujillo et al., 1962) belongs to the same group of causes is not 

 known at present. 



In suggesting basement membrane damage as a general cause of late 

 lethal effects, I have chiefly mentioned the renal consequences. A second 

 target organ may be the waU of large arteries, where the endothelial basement 

 membrane is shown to be damaged. 



REFERENCES 



Bargmann, W. (1958). Dtsch. Med. Wschr. 83, 1704. 



Braams, R. (1961). Int. J. Bad. Biol. 4, 27. 



Braams, R., Hutchinson, F., and Ray, D. (1958). Nature, Lond. 182, 150G. 



Bunting, C. H., and Bunting, H. (1953). Arch. Path. 55, 257. 



Casarett, G. W. (1959). In "Radiobiology at the Intracellular Level", p. 132. Pergamon 



Press, London. 

 Curtis, H. J. (1960). "Medical Physics", Vol. 3, p. 492. The Yearbook Publishers, 



Chicago. 

 Curtis, H. J. (1961). Proc. 3rd Australasian Conf. on Radio-biology, p. 114. Butterworths, 



London. 

 Day, T. D. (1959). Quart. J. exjy. Physiol. 44, 182. 

 DoBZHANSKY, T. (1958). Ann. N.Y. Acad. Sci. 71, 1243. 

 DoRFMANN, A., and Schiller, S. (1960). "Biological Structure and Function", p. 327. 



Academic Press, New York. 

 Doty, P., Marmur, J., Kigner, G., and Shildkraut, C. (1960). Proc. nat. Acad. Sci., 



Wash. 46, ^61. 

 Failla, G. (1958). Ann. N.Y. Acad. Sci. 71, 1124. 



Farquhar, M. G., Wissig, S. L., and Palade, G. E. (1961). J. exp. Med. 113, 47. 

 FiTZPATRiCK, C. T., Brunet, P., and Kukita, A. (1958). In "The Biology of Hair 



Growth" (W. Montague and R. A. Ellis, eds.). Academic Press, New York. 

 Gersh, I. (1952). Harv. Led. 45, 216. 



Gersh, L, and Catchpole, H. R. (1960). Pers^Kct. Biol. Med. 3, 282. 

 Glass, B. (1960). In "Ageing — Some Social and Biological Aspects", Publ. Amer. Ass. 



Adv. Sci. No. 65. 

 Guttman, p. H., and Kohn, H. I. (1960). Amer. J. Path. 37, 293. 

 Henshaw, p., Stapleton, G., and Riley, E. F. (1947). Badiology 49, 349. 

 Illig, L. (1961). "Die terminale Strombahn". Springer, Berlin. 

 Jellinek, S. (1958). Lancet i, 1149. 

 Joseph, N. R., Engel, M. B., and Catchpole, H. R. (1952). Biochim. biophys. Acta 8, 



575. 

 KiTAGAWA, T., Glicksman, A. S., Tyree, E. B., and Nickson, J. J. (1961). Radiation 



Res. 15, 766. 

 Korenchevsky, v. (1961), "Physiology and Pathology of Ageing", p. 50. Karger, Basel, 



New York. 



