210 



H. B. LAMBERTS 



thiosulphate is very low which gives us the possibility of flooding animals, and 

 eventually patients, wdth the substance. These considerations make it worth- 

 while to study the influence of NaaSgOg on non-neoplastic long-term radiation 

 effects, in particular on the vascular effects and shortening of life-span. 



Q 



I30r- 



110- 

 90 



70 

 50 

 30 



10 



J_ 



350 400 450 500 550 600 650 700 750 800 



m/i 



Fio. 8. Spectrophotometric estimation of the amount of haematoporphyrin diffusion in the 

 intimal membrane of the rat aorta. 



Brolven lines: aortae of rats irradiated with 3,000 r. 

 Solid lines: aortae of unirradiated, control rats. 



REFEKENCES 



Brinkman, R., Lamberts, H. B., Wadel, J., and Ztjideveld, J. (19G1). Int. J. Bad. 



Biol. 3, 205. 

 Gersh, L., and Catchpole, H. R. (1960). Perspectives Biol. Med. 3, 282. 

 Gold, H. (lOf,!). Arch. Path. 71, 268. 

 Kjrk, J. E. (1959). "The Arterial Wall" (A. J. Lansing, ed.). WiUiams & Wilkins, 



Baltimore. 

 Koch, R., and Schenk, G. 0. (1961). Strahlentherapie 116, 364. 

 Lindsay, S., and Chaikoff, I. L. (1955). Arch. Path. 60, 29. 



Lindsay, S., Kohn, H. J., Dakin, R. L., and Jew, J. (1962). Circulation Pes. 10, 51. 

 Perez-Tamayo, R. (1961). "Mechanisms of Disease." W. B. Saunders, Philadelphia. 

 Weiss, P. (1962). "The Molecular Control of Cellular Activity" (J. M. Allen, ed.). 



McGraw-Hill, New York. 



DISCUSSION 



UPTON: I would like to enquire about the relationship between the observed effects and 

 dose. First, can you get demonstrable effects with doses substantially lower than 1,000 r 

 in vitro or in vivo'! Secondly, do you have any idea how much dose reduction you got with 

 thiosulphate? 



