ETHYL METHANE SULPHONATE 265 



tracer work by Roberts and Warwick of this Institute has revealed no organ selectivity at 

 all. From the cancer chemotherapy point of view one would of course be delighted if 

 compounds didn't get everywhere and remained in a few places but none have been 

 found to do this to any marked extent. 



muller: I just want to say we might be talking at cross-purposes if we simply say that 

 this or that observation is for or against the somatic mutation hjrpothesis because I think 

 you were using the somatic mutation hypothesis to mean somatic point-mutation. In 

 fact Curtis was using it in a more general sense too, including chromosome aberrations. 

 ALEXANDER: I was stressing point-mutation because, for these, ethyl methane sulphonate 

 is so very effective. 



