RADIATION-INDUCED LIFE-SPAN SHORTENING IN MICE 283 



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DISCUSSION 



CURTIS: I would just Uke to point out that in some strains of mice with a high spontaneous 

 leukaemia rate irradiation reduces the incidence of this disease. 



berenblum: The small amount of radiation dose, which in C57BL mice raises the inci- 

 dence of leukaemia from about 2% to 40-50%, reduces the leukaemia incidence in AKR 

 mice, from 70-80% in the controls to 40-50%. 



CURTIS: I thmk all we are saying really is that radiation leukaemogenesis is not a simple 

 process, it is a combination of processes and I don't think that we should try to generahze 

 it and put it all in one box. 



ALEXANDER: One thing seems clear, radiation does not accelerate ageing m the sense of 

 speeding up the "internal clock" of the animals so that cell changes, physiological and 

 pathological, occur in the same order but are moved forward in time. 



