68 



J. A. V. Butler 



Table II 



Specific Radioactivities of Protein and Nucleic Acid Fractions from 



Rats Administered with a ^''C-labelled Nitrogen Mustard p-Di(2- 



Chloroethyl)amino-dl-Phenylalanine. (Experiments by P. Cohn.) 



* Purified by precipitation with ethanol. 



In the absence of precise knowledge of the functions of these 

 substances, it is difficult to say what effects might be expected 

 to follow from these reactions. However, it is obvious that 

 reaction with DNA and RNA will not only interfere with their 

 ability to reproduce themselves but also with their metabolic 

 functions. 



Table III 



Comparison of Inhibitory Effect of Some Aromatic Nitrogen Mustards 



ON THE "Exchange Reaction" in Staphylococcus awrej/s with the Inhibition 



OF Growth of the Transplanted Walker Carcinoma. 



(Experiments by G. D. Hunter and A. R. Crathorn.) 



