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DISCUSSION 



Latarjet: You quoted experiments of Nizet, Lambert and Bacq, who 

 found stimulation of liaemin synthesis by irradiated reticulocytes. The 

 stimulation of normal biological functions by radiations themselves or 

 by their chemical intermediates has always been surprising, and has 

 even been questioned. May I point out in connection with this that 

 Dr. Monier in my laboratory has treated pepsin with very small amounts 

 of an organic peroxide, and has found an increase, by a factor of 1 • 5, in 

 the enzymatic activity. 



Van Bekkum: Dr. Pirie, you quoted data from Altman, Richmond and 

 Solomon in your Table II ; as far as I know, these experiments have not 

 been repeated by others so far and the evidence in support of an increase 

 in fatty acid synthesis is very meagre indeed, because each figure you 

 showed was derived from one rabbit only, and the authors did not 

 indicate the variation in the control rabbits. 



Pirie: It was whole body irradiation, so they could not take one leg 

 and use the other as a control. Have you got similar reservations about 

 the data on increase in synthesis of haemin and globin? 



Van Bekkum: I do not have reservations of the same kind but I have 



