Radiation and Regenerating Rat Liver 



231 



The total activity of the CO2 is given as a percentage of the 

 total activity of the glucose of the medium. The oxidation of 

 glucose, as measured by this method, includes the direct 

 oxidation of C^ and the oxidation of the derived three-carbon 

 molecules through the Krebs cycle. 



Fig. 2 shows an increase in total glucose oxidation after 

 hepatectomy. This can be seen here related to the other 

 metabolic changes and to the mitotic cycle. 



Table II 



The slices were incubated in Krebs-Ringer phosphate solution containing 

 0*4 per cent glucose. 



* Statistical comparison shows that these figures are signiflcantly higher than normal. 



The comparison of samples of glucose specifically labelled 

 in the 1- and in the 6- position shows that both the direct 

 oxidation of glucose which results in the liberation of COg from 

 Ci and the oxidation through the Krebs cycle, which results in 

 liberation of COg from Cg as well as from C^, are very definitely 

 increased after hepatectomy. These figures will be published 

 later by Dr. Itzhaki. 



A large number of measurements of respiration and of fat 

 content were made at 26 hours after hepatectomy and the 

 mitotic rates were measured by Dr. Cater. No connection 

 between the mitotic count and the respiration or fat content 

 could be demonstrated. 



