i 



232 



Barbara E. Holmes 



Although it is well known that X-ray irradiation tends to 

 have very little immediate effect on the general metabolism 

 of a tissue, it did seem possible that an irradiation dose cap- 

 able of delaying the regeneration of the liver might also 



+IIO 



Fat 



Oj uptake 

 D — Glucose Oxidation 

 ® Mitosis 



r-35 



O 

 -30 o 



9 



■25 g 



o 

 o 



-20 



O 



-si 



2 



-lO 



-i — I — T 1 r 



12 16 20 26, 36 

 Hours 



44 48 

 Period alter Hepatectomy 



-I — I — r 

 Days 



-5 



\ ^O 



Fig. 2. Fat content, oxygen uptake and glucose oxidation of regenerating 



liver. 



delay the appearance of increased respiration and increased fat. 

 This, however, was not the case, as Table III shows, even when 

 the rat was irradiated before hepatectomy. 



The glucose oxidation, as measured by COg output in the 

 manner already described, gave somewhat different results, 

 which are shown in Table IV. The oxidation of glucose by 

 normal liver was unchanged by irradiation, but the increase in 

 glucose oxidation found during early regeneration could be 



