Radiation and Regenerating Rat Liver 



233 



inhibited by 450 r X-rays given before hepatectomy. The 

 glucose oxidation has, in fact, been prevented from rising 

 above the normal level in animals which are killed at 15 or 16 

 hours after hepatectomy, which is the only time interval so 

 far used. The glucose oxidation at the time of recovery from 

 irradiation must obviously be measured as soon as possible. 



Table III 



Effect of Radiation on Oxygen Uptake and Fat Content of 



Regenerating Liver 



Values for normal liver: Og uptake 6 • 67, fat content 3 • 64. 



* This rat was irradiated immediately before hepatectomy. 



All these measurements were calculated on the basis of the 

 weight of fat-free dry tissue, since the fat content was 

 sometimes very high in the regenerating tissue. The effects of 

 X-rays on glucose oxidation will be published in more detail 

 later. 



In the course of the irradiation experiments just described, 

 it could always be shown that 450 r given during or at the end 

 of DNA synthesis, although too late to prevent the synthesis, 

 still had a marked delaying and damaging effect upon mitosis. 

 We hoped to demonstrate, by another type of experiment, a 



