308 General Discussion 



the way to the control of the disorders of metabolism which are 

 brought about by ionizing radiations. 



I think it has been very well worth while coming here for all sorts 

 of reasons, not least to hear Professor de Hevesy say what he said a 

 short while ago. I thought this was a very moving and masterly 

 summary. He was obviously impressed by what he called the fairy 

 tale which Dr. Loutit has told us, and I think we are specially grate- 

 ful to Dr. Loutit for recalling the early key observations, particularly 

 those of Jacobson, and the later work of Lorenz who is so well 

 remembered in the Ciba Foundation. I have a feeling that the pro- 

 gress of work depends rather on the making of such key biological | 

 observations. We must not detract from the skill or prowess of the 

 biochemist ; but from my own experience, with all respect to my 

 biochemical confreres, I find that very seldom are they able to direct 

 one to make the discovery. The discovery very often having been 

 made by the biologists, they can then explain it in many cases, or 

 endeavour to do so. And this leads me to another impression I have 

 had during this meeting: that we more and more approach the j 

 holistic view of the cell. As Dr. Zamecnik showed so graphically, ^ 

 atoms and molecules tend to mean very little in themselves, and it is 

 the way in which they are put together that really matters. We will 

 all recall for a very long time to come the courage shown by Krebs in 

 throwing his paper and slides out of the window. Lastly I should 

 like, from myself and on your behalf, to tender thanks to Dr. 

 Hollaender, Professor Butler, Dr. Gray and Dr. Wolstenholme, for 

 all their help in the early arrangements of a profitable and memorable 

 Symposium. 



