PKOTEINS AND NUCLEIC ACIDS IN SOLUTION 57 



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DISCUSSION 



BACQ : Wliat is the relative efficiency of the a-particles and X-rays witli regard 

 to the enzyme system you have studied? 



passynsky: Up to now X-rays alone have been studied. Comparison with the 

 effects of a-particles is vmdoubtedly of the greatest interest, since until now 

 different models always differed from the living cell by the relative efficiency of 

 different irradiations. 



gray: How do the radiation effects depend on the thickness of the RNP layer 

 around the enzyme particle? 



passynsky : We tried to obtain layers as thin as possible, but the influence of the 

 irradiation up to now has only been studied for the minimum thickness obtained 

 — about 8 molecular diameters. 



ARDASHNiKOV: What is the explanation for the irradiation dose effect? 

 PASSYNSKY : At a given dose in every monolayer an equal number of the structural 

 lesions would be produced, irrespective of the number of the successive layers. 

 But the effect of these lesions on the permeability of a separating layer of course 

 would not be the same, if the layer's thickness varied. In a layer consisting of one 

 row of molecules every lesion would change the permeability ; whereas in the case 

 of a multi-molecular layer it is necessary that lesions of different layers should 

 form a kind of channel, and that is an unlikely occurrence. Just because of this 

 it may be expected that the sensitivity of the system to irradiation would in- 

 crease rapidly. 



