148 



N. N. DOEMIN AND V. D. BLOKHINA 



lipid content of the cytoplasmatic organelles of the liver is extending 

 low, the content of "free" lipid in the mitochondria and microsomes of 

 the intestinal mucosa is high and amounts to 35 and 22 per cent re- 

 spectively of the total lipid content. On the other hand, the relative 

 content of tlie li])id fractions in the hyaloplasm in both tissues is very 

 similar. 



o 



Normal 2 



Hours after irradiation 



Fis. 4. The content (percentage of dry weight) of various lipid fractions in cell micro- 

 somes of the intestinal mucosa of rabbits under conditions of acute radiation disease: 



curves as in Fig. 1. 



The changes in the total li})id content and its fractions in the cells of 

 the intestinal mucosa following irradiation also diflFei*ed considerably 

 from the picture observed in the liver. The comparative study of data 

 obtained 24 and 72 hr after irradiation supports this conclusion. 



It should be stressed that in the case of the intestinal mucosa the 

 separate investigation of mitochondria and microsomes established 

 that the direction of the changes may differ. The relative content of the 

 "firmly bound" lipids 2 and 24 hr after exposure showed a reduction 

 in the microsomes while in mitochondria there was a tendency for it to 

 increase (72 In^ later relative content of the "firmly bound" lipids in- 

 creased also in the microsomes). As to the content of the "loosely bound" 

 lipids, immediately after exposure it fell considerably in the microsomes ; 

 on the contrary in the mitochondria it showed a marked initial increase 

 and a reduction began only later. The relative content of "free" lipids 

 rose significantly in the microsomes, whereas in the mitochondria it 

 showed no difference from the control (it was even halved by the second 

 hour following exposure). 



This observation \\\U bring us l)ack again to the liver analysis; the 



