CHANGES IN LIPIDS OF CELLULAR MICROSTRUCTURES 



149 



aim oi w Inch is to levoal post-exposure separate alterations in the liver 

 mitochondria and microsomes. 



Contrary to the observations for the liver cells, the mitochondria 

 and the microsomes in the small intestinal mncosa showed no progres- 

 sive reduction in their content of "firmly bound" lipids. Indeed, as 

 noted above, this content had a tendency to increase (es]iecially in the 

 mitochondria). In this case the absolute quantity of this fraction 

 exceeded the control (except the reduction in the microsomal content 



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5 



-a 



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 en 

 D 



(LI 

 Q_ 





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\ 



I[ 



_L 



Normal 2 



24 

 Hours after irradiation 



72 



Fig. .5. The content (percentage of dry weight) of various lipid fractions in the hyalo- 

 plasm of the intestinal mucosa cells of rabbits under conditions of acute radiation 



disease; curves as in Fig. 1. 



24 hr after irradiation). The content of the "loosely bound"' lii)ids in 

 the cytoplasmic organelles of the small intestinal mucosa showed a 

 tendency to fall, whereas the content of this fraction in the liver cells 

 was rather stable. 



The increase of the total lipid content in the hyaloplasm of the small 

 intestinal mucosa cells, contrary to the data obtained in the liver studies, 

 was accompanied by pronounced changes between the lipid fractions 

 with a reduced amount of "free" lipids and relative increase for the 

 "firmly bound" ones. 



Thus, the radiation injury resulted in pronounced disturbances of 

 the lipid composition of the morphological components also of the cells 

 of the intestinal mucosa in rabbit, but these alterations differed from 

 the ones observed in the liver tissue. 



It is of interest to note that the considerable shifts in the lipid 



