HISTOLOGICAL CHANGES AFTER IRRADIATION 



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Fig. 17-3. (A) Metaphysis of tibia of untreated rat showing the interdigitation of 

 primary spongiosa with cartilage; 35 X. (B) Metaphysis of rat 9 days after 600 r 

 total-body X rays (200 kv). Note the complete severance of the bone of the meta- 

 physis from the cartilage; 40 X. ((') Metaphysis of mouse femur 90 days after 3.6 

 Mc/g of Sr 89 . There has been severance of the spongiosa from the epiphyseal plate and 

 the cartilage has become markedly thickened, with swelling of the cells; 50 X. (D) 

 Metaphysis of mouse femur 40 days after 1 A<c/g of radium. Note areas of newly 

 formed, atypical bone in the marrow; 105 X. (After Heller, 1948.) 



