EXPERIMENTS WITH CYTOST 95 



The toxicity of such preparations was ascertained 

 by injection into the femoral vein of anesthetized cats. 

 When administered in this fashion, 1.5 cc. of such a 

 preparation caused death of the animal within 1 or 

 2 minutes. As in the other acute experiments which 

 we have considered, immediate autopsy always dis- 

 closed marked congestion of the lungs and abdominal 

 viscera. When injected intraperitoneally, intramus- 

 cularly, or subcutaneously, such cytost extracts do not 

 cause immediate congestion and death, but, depend- 

 ing upon the dosage, bring about different pathologi- 

 cal conditions, as shown in the following experiments 

 selected from many recorded in the author's labora- 

 tory notebooks. 



No. 73 



Male cat, weight 343 gms. 



March 29, 1920. Temperature 101.4°. 1 cc. injected intraperi- 

 toneally and 1 cc. subcutaneously. 

 March 31. Similar injections. Temperature 102°. 

 April 4. Similar injections. Temperature 102.2°. 

 April 6. Animal died. 



Autopsy : stomach congested, dilated ; duodenum, congested ; 

 intestines hemorrhagic ; spleen enlarged ; kidneys congested. 



Castrated male cat. Weight 2980 gms. 



March 31, 1920. 1 cc. injected intraperitoneally and 1 cc. subcu- 

 taneously. Temperature 101°. 



April 4. Similar injections. Temperature 101.6°. 



April 8. Sick, temperature 103.8°. Weight 2210 gms. 



April 10. Weak, does not eat, temperature 102.5°. Weight 2000 

 gms. 



April 11. Temperature 99° ; exit. 



