RELEASE OF CYTOST 



61 



TABLE II 



Dogs 



In these experiments loops of intestine were tied off as indicated in the second 

 column. Submucous juice was withdrawn from the loops after the periods 

 noted in the third column. This was diluted with an equal volume of normal 

 salt solution and the quantities of the extract noted in the fourth column were 

 injected intravenously into the animals. This always caused death within 

 from three minutes to twenty-four hours, as shown in the fifth column. 



enzymes but by those exterior to the cells as well. Now 

 enzymatic action is known to be greater in the upper 

 alimentary tract than at lower levels. It follows that 

 for a given injury, the cells lining the upper portion 

 of the tract must be more rapidly autolyzed than those 

 at lower levels. As a net result the concentration of 

 cytost necessary to cause generalized symptoms is more 

 rapidly released than is the case in lower levels of the 

 intestine. Thus we arrive at an adequate theoretical 

 basis for the results observed in these experiments. 



The results of these experiments are in harmony 

 with the author's early contention that a tissue tox- 

 emia frequently caused death from shock during ob- 

 dominal operations. (Turck, 1901.) Further, they 

 of]fer a rational explanation for the statement that "in 



