RELEASE OF CYTOST 55 



in the various pathological processes. In the case of 

 stomach ailments, various experiments were devised 

 to ascertain the presence and the nature of toxins 

 formed in the stomach. In the previous chapter we 

 have referred to experiments which showed that the 

 injection of the gastric contents of patients suffering 

 from gastritis produced signs of toxemia and shock. 

 Clinical observers have repeatedly noted symptoms 

 of so-called auto-intoxication in patients with gastric 

 atony and dilation. This suggested a study of the 

 fatigue of gastric muscle. Experimentally it was 

 found that the gastric muscle could conveniently be 

 fatigued in either of two ways: by rapidly revolving 

 the gyromele with the stomach; and by alternately 

 inflating and collapsing a rubber bag inserted into 

 the stomach. (Turck, 1903a.) By either of these 

 means the muscles may be so completely fatigued that 

 they fail to respond to stimuli, and show marked 

 elongation and lack of tone. After such treatment por- 

 tions of the stomach tissues were subjected to histologi- 

 cal examination whereby the muscle fibers of the py- 

 lorus were found to have suffered the most marked 

 changes, the nuclei staining poorly with methylene 

 blue while the cytoplasm appeared to be less granu- 

 lar than normally. These latter observations are indic- 

 ative of autolysis and show that injury of the stomach 

 tissues is followed by morphological changes analo- 

 gous to those found in other tissues under similar con- 

 ditions. Further congestion and dilation of the capil- 

 laries was evident. These histological findings are 

 in agreement with Oilman's (1903) observations on 

 the effect of fatigue on the nuclei of voluntary muscle 

 cells. 



