SHOCK 39 



of shock. Died on third day. Postmortem revealed no evidence of 

 infection. Cultures negative. 



Experiment 17. Small black and tan under chloroform. Blood 

 pressure, 130. Serum used from a dog which had been under anes- 

 thesia five hours, and bled the following day; 25 cc. of serum in- 

 jected. Fifteen minutes, pressure fell to 115; twenty minutes, 110; 

 thirty minutes, 95 ; 25 cc. serum injected. Blood pressure, 15 

 minutes following the last injection, 65-70. Wide excursion. Anes- 

 thesia removed. Animal died the following day. 



Experiment 18. Mongrel bull. Ether anesthesia. Blood pres- 

 sure 150. Serum from an animal that had been under ether for 

 four hours. The animal had been bled immediately after removal 

 of the anesthetic. Injection of 22 cc. followed by another injection 

 of 22 cc. No effect on blood pressure, 20 cc. more no effect on blood 

 pressure; 20 cc. pressure 100. In one hour pressure 85. Anesthetic 

 withdrawn and animal recovered. 



Experiment 22. Dog, yellow; temperature 38.8°. Injected serum 

 from animal six hours under anesthesia. Temperature, 38.3°. 

 Amount injected, 25 cc. and 20 cc. Temperature went down to 

 37.2°. The following day rectal temperature 38.3°. Animal list- 

 less ; cannot be around, and lips appear pale ; marked loss of sensa- 

 tion. Second day, temperature 39.5°. Animal depressed; marked 

 loss of appetite. Fourth day, animal bled ; shows rapid coagulation 

 and taking. 



At this point it should be noted that when animals 

 are anesthetized for a period sufficiently long to in- 

 duce shock, invariably it is found that the coagulation 

 time of the blood is shortened. We shall reserve dis- 

 cussion of the significance of this observation for a 

 later chapter, but it may not be amiss here to note that 

 an increased ease of coagulation of the blood will 

 facilitate clogging of the capillaries and hence con- 

 gestion in the larger vessels — a characteristic phe- 

 nomenon in all cases of shock regardless of the means 

 by which this unique physiological state is induced. 



For a long time it has been common knowledge that 



