EXPERIMENTS WITH CYTOST 101 



Cat No. LI I 



June 4, 1919. Leg tied off. Fifteen minutes later injected 1 cc. 

 chloroform. After 1 hour ligature removed. 



June 5, 9:15. Respiration rapid and weak. Rales in lungs. 

 Mucous membranes pale. Taken from cage and laid on desk, 

 is relaxed, does not move. Raises head for an instant but can- 

 not hold it up. 



10:15. Gasps for breath. Temperature 38.5°. Respiration 

 and heart stopped. 



10:20. Autopsy: Lungs, lower lobes engorged, hemorrhagic; 

 liver, stomach and upper intestines congested. 



When fluid was withdrawn from the site of the in- 

 jection and injected into other animals, the latter 

 showed a typical response, as demonstrated in the 

 following protocol. 



Cat No. XXII 



March 1, 1919. 2:00 P.M. Temperature 40°. Four cc. of auto- 

 lytic products, resulting from the injection of ether into the 

 leg of another cat, were injected subcutaneously. 

 2:30. Temperature 38°. 



March 2. Eats. Temperature normal. 



April 14. Animal very thin. 



April 20. Thin, coughing. 



April 26. Extremely thin. Constantly coughing and sneezing. 



May 6. Does not eat. Staggers. 



May 11. Found dead. 



Autopsy: Lungs, pneumonic spots, and spots resembling tu- 

 bercules; liver, congested; stomach and intestines, congested, 

 hemorrhagic areas and apparently ulcers in intestines; kidneys, 

 congested. 



Such experiments as these show definitely that cy- 

 tost liberated in vivo by the action of chloroform, 

 ether, and alcohol leads to the same pathological end 



