102 THE ACTION OF THE LIVING CELL 



as does cytost from autolyzed tissues. In both in- 

 stances the primary congestion results in damage of 

 the tissues of endodermal origin. 



When somewhat smaller quantities of cytost are in- 

 jected or liberated in vivo much the same results may 

 be obtained, but a much longer period of time is neces- 

 sary before the pathological changes become appar- 

 ent. In this connection the reader may recall the pro- 

 duction of kidney lesions by superficial burns and by 

 the repeated injection of small quantities of chloro- 

 form and ether (page 92). Similarly, repeated in- 

 jections of small quantities of tissue autolysates re- 

 sult in the production of chronic lesions. The results 

 of some experiments of this nature are summarized in 

 Table IX. The cytost preparations were prepared as 

 stated in the preceding protocols. 



Aside from the resulting pathology, the marked 

 loss in weight of the experimental animals is interest- 

 ing. This may be taken as indicative of a lowered 

 metabolism. On the basis of these experiments alone 

 one cannot decide whether this is due primarily to 

 the action of the cytost on the body cells, or to im- 

 paired circulation resulting from blood stasis induced 

 by the cytost. 



In the writer's experience, gastrointestinal ulcers 

 are rare in cats; hence he is forced to conclude that 

 those found in the animals injected with cytost were 

 due to the prolonged action of the latter on the gastro- 

 intestinal mucosa, which, like the other tissues sensi- 

 tive to cytost, arises from the endoderm of the early 

 embryo. 



As is now well known, in the adult animal ingested 

 foods are for the most part utilized as a source of 



