84 THE ACTION OF THE LIVING CELL 



nection with his experiments on inflammation of the 

 stomach. At that time, while considering the patho- 

 logical changes induced by the introduction of caustics 

 and bacteria into the stomach, it was concluded that 

 "it seems that the entoderm is far more sensitive to 

 irritation than the ectoderm." 



In the foregoing discussion it has been shown that 

 cytost appears to act selectively on the endodermal 

 cells and thus affects the adjacent blood in the capil- 

 laries of the various viscera. When autolyzed tissue 

 is injected into an animal, the pathological lesions pro- 

 duced in the lungs resemble those of other visceral tis- 

 sues (Fig. 3). Since the capillary network of the air 

 sacs is the most dense capillary plexus of the body, and 

 material may be introduced into the lung without 

 recourse to experimental surgery, the lung appeared 

 to offer an excellent site for the investigation of the 

 localized stasis induced by cytost. To this end, auto- 

 lyzed tissue was introduced into cats' lungs. The re- 

 sults of these experiments, which are summarized in 

 Table VI (Turck, 1919), were far more striking 

 than could possibly have been imagined. 



The experiments were conducted as follows : Fresh 

 lung tissue from healthy cats was autolyzed in a 

 sterile chamber of chloroform vapor for forty-eight 

 hours, when the mixture was found to yield an in- 

 tense biuret reaction. By means of a tube attached 

 to a respiratory indicator, 0.5 to 1 cc. of such auto- 

 lyzed tissue suspension was insufflated into the 

 tracheae of normal cats. The animals' increased in- 

 spiration aspirated a portion of the material into the 

 finer bronchii, and in many instances, as shown in 

 Table VI, caused the animal's death within four or 



