EXPERIMENTS WITH CYTOST 



lis 



Eight healthy pregnant cats were daily injected in- 

 traperitoneally with 1 cc. of cytost. As might be ex- 

 pected from what has been said above, the cats devel- 

 oped various pathological conditions of the viscera 

 which caused the death of two of the mothers. Five of 

 them gave birth to dead kittens, while all but one of 

 the kittens born alive died shortly after birth. Data rel- 

 ative to these experiments is recorded in Table XI. 



TABLE XI 

 Effects of Large Doses of Cytost on Mothers and Offspring 



From these results it follows that the injected cytost 

 affected the kittens as well as the mothers. That this 

 is entirely possible is shown by the fact that when 

 shock was induced in a pregnant animal, the embryo 

 was found to suffer marked stasis of the blood in much 

 the same manner as did the mother. In figure 12 is 

 reproduced a photomicrograph of a guinea pig em- 

 bryo in utero of a mother which had been subjected 

 to fatal shock. Examination of this section discloses 



