PHYSIOLOGY OF CYTOST ACTION 91 



higher concentration of cytost was introduced into 

 the circulation than is the case when natural absorp- 

 tion of the burned tissue is permitted to take place. 

 Consequently the onset of symptoms in this series of 

 animals is much more rapid, as shown in Table VIII. 



TABLE VIII 



At autopsy, all the animals listed in Tables VII and 

 VIII showed the same general pathology as that 

 previously described in the earlier experiments with 

 cytost. However, in this series of experiments special 

 attention was directed to the involvement of the kid- 

 neys. Quite striking was the observation that within 

 five minutes after the intravenous injection of the ex- 

 tract of charred tissue, kidney lesions, usually in the 

 form of a glomerulitis, could be detected. This was 

 determined by removal and sectioning of the organ. 



It was further observed, as might be expected, that 

 in general the type of kidney involvement varied 



