88 THE ACTION OF THE LIVING CELL 



lungs. The temperature at first dropped and later 

 rose, but the temperature records were no guide to 

 the degree of lung involvement." 



At autopsy, the findings were of a nature similar to 

 those observed in the preceding series of experiments, 

 wherein the autolysate was introduced by insufflation. 

 In agreement with the observations on shock pro- 

 duced by various means, the blood was early found 

 to have a high viscosity and diminished clotting time. 

 This, as we have seen, may be an important factor in 

 the development of capillary stasis. 



Results identical with those discussed above were 

 obtained many times with different series of animals 

 and were not therefore due to a chance infection in 

 one particular group. As a control upon these obser- 

 vations, pneumococcus cultures, types I, II, III, and 

 IV, were insufflated into the trachea of cats. No pneu- 

 monia was produced, provided "flooding" of the lung 

 was prevented. 



In the "cats' paw" series of experiments, the amount 

 of cytost which found its way to the animals' lungs 

 must have been exceedingly small. Indeed, that the 

 amount necessary to elicit a typical lung involve- 

 ment is minute to a degree was found in another series 

 of experiments wherein the autolyzed tissue was not 

 applied directly to the animals, but was merely 

 sprayed about their cages by means of a nebulizer. 

 Cats kept in such cages were found to develop respira- 

 tory involvements in much the same manner as the 

 animals whose paws had been smeared with a paste 

 of autolyzed lung tissue. At autopsy the findings 

 were identical with those recorded in the latter case. 

 (Turck, 1919.) 



