PHYSIOLOGY OF CYTOST ACTION 87 



the bronchial mucosa, giving rise to classical pneu- 

 monitis of the bronchial type. It follows, therefore, 

 that such an extension is secondary to the primary 

 reaction in the capillary plexus. It is interesting to 

 compare this action with that in the abdominal vis- 

 cera, where, it will be remembered, the primary stasis 

 was found to occur first in the capillaries, then ex- 

 tending to the larger vessels. These observations lead 

 one to believe that the primary reaction to "shock- 

 toxin," or cytost, is always in the endodermal cells and 

 then extends to the capillary endothelium. 



As, conceivably, one might consider the insuffla- 

 tion technique to involve the complicating factor of 

 introducing a liquid into the lung, experiments of 

 another type were conducted. (Turck, 1919.) "A 

 group of ten cats was selected and examined to ex- 

 clude any respiratory disturbance and then placed 

 in a large cage. The front paws of five of these ani- 

 mals were coated with a thin paste of autolyzed cat 

 lung tissue. The animals were tagged, and placed 

 back in the cage with the other five cats that had not 

 had the application of 'lung paste.' Within two hours, 

 several of the cats began to sniffle and sneeze. Within 

 twelve hours all the cats, those that had had their 

 paws coated and the others in the same cage that had 

 not had the application of paste, had symptoms of 

 involvement of the lungs. Eight of these cats died 

 from pneumonia within 48 hours to one week after the 

 application of the lung paste. Some of the animals 

 showed extensive respiratory pathological conditions. 

 They also showed nasal discharge, eyes reddened, con- 

 junctive discharging and extensive rales over both 



