CYTOST IN MEDICINE 261 



ditions. Now the same end should follow the release 

 of cytost by any means whatsoever. 



In consequence one may regard a focal infection 

 simply as one means of causing the accumulation of 

 excessive quantities of cytost in the individual. If this 

 view be accepted, we may readily account for the ab- 

 sence of a bacteriemia in individuals supposedly suf- 

 fering from the effects of foci of infection. Further, 

 this concept enables one to understand the fact that 

 the removal of such foci does not necessarily guar- 

 antee the patient relief, for he may suffer from cytost 

 arising from another cause, or from the cytost released 

 by the infection, which is not removed from his body 

 when the focus is cleaned up. 



In order to ascertain the possibility of causing in 

 animals a condition similar to that of arthritis in man, 

 cytost preparations were injected into the bone mar- 

 row of cats. This was accomplished by trephining 

 small openings in the proximal end of the tibia and 

 the distal end of the femur. One eighth of a cubic 

 centimeter of a 10% solution of an active cat tissue 

 ash was then aseptically injected directly into the 

 bone marrow through each of the two openings. As 

 a control, other cats were injected similarly with cor- 

 responding quantities of horse and lion cytost. The 

 cats receiving the cat cytost in this way developed a 

 marked lameness, with stiff and sensitive joints, which 

 lasted for several days. The animals injected with 

 horse cytost showed no ill effects, while those which 

 had been injected with lion cytost developed a slight 

 lameness which lasted for two days only. (Turck, 

 1921.) 



Further experiments showed that the injection of 



