CYTOST IN MEDICINE 263 



increase in pain and sensitiveness. For this purpose 

 we have employed a saline extract of the gray ash of 

 human muscle. When heterologous cytost is injected 

 similarly the only additional pain experienced is that 

 which normally follows the intramuscular injection 

 of almost any non-irritating solution. 



The fact that injections of homologous cytost mark- 

 edly accentuate the pain and soreness for which pa- 

 tients seek treatment is of diagnostic significance, for 

 it indicates that the patient's tissues are hypersensitive 

 to cytost. This may be due to either of two causes : his 

 tissues may be naturally hypersensitive — i.e., his re- 

 sistance to cytost is low; or because of an unduly large 

 amount of cytost already present, the additional quan- 

 tity introduced in the injection may raise its concen- 

 tration in the tissue fluids to an abnormally high de- 

 gree. In either case the end result is the same. The 

 writer believes that when an individual is found to 

 be hypersensitive to cytost the conclusion is war- 

 ranted that such an individual is suffering from cytost 

 intoxication. 



Now the question arises as to how one is to over- 

 come this condition, — that is, can we ofifer the patient 

 any relief from the effects of cytost upon his tissues? 



The answer to this question is to be found in the 

 results of our laboratory experiments on animals. It 

 may be recalled that we were able to obtain evidence 

 that an animal's resistance to cytost may be materially 

 raised by a properly regulated series of injections of 

 homologous cytost. Because of this it appears logical 

 that one should be able to do the same with humans. 

 Elsewhere the writer has described the treatment of 

 various diseases by this means. 



