494 Second European Journey 



Section on Public Health and Medical Science and the American 

 Association for Cancer Research. Immediately he sent brief notices 

 of the discoveries to Science ^^ and the journal of the American 

 Medical Association/'^ He included the above-quoted materials in 

 an article ^^ sent to the Journal of Cancer Research, nev^, official, 

 publishing organ of the cancer research association. On April 18, 

 1916, he read before the National Academy of Sciences a paper 

 entitled " Further evidence as to the relation between crown gall 

 and cancer." *^° After this occasion, " many individual members 

 [visited the} hot houses to look at [his] inoculated plants." ^^ 



April 29 Smith reported to Dr. MacCarty of the Mayo Labora- 

 tories: 



You will be interested to know that I had a string of distinguished 

 zoologists and physicians to look at my inoculated plants during the 

 meetings of the National Academy of Sciences in the week following your 

 visit here, and all of them expressed themselves as greatly interested, and 

 some of them went much further than that. . . . 



The inoculated plants bearing teratoids have developed considerably 

 further since you saw them, and a number of them are now dying with the 

 disease. I had half a dozen photographs of these plants made today and 

 will have about as many more made on Monday, to use as slides before the 

 Ninth Annual Meeting of the American Association for Cancer Research, 

 which begins here in Washington at the Willard Hotel on Monday, May 8, 

 1916. . . . 



Something quite interesting is now visible on the inoculated plants of 

 Ricinus which was not visible when you saw them. The tumors in the leaf 

 axils have in a number of instances stimulated the neighboring glands on 

 the leaf stalks so that they have become cancerous and have enlarged 100 

 times or more the normal size of the glands. This is extremely suggestive 

 of what I saw in your laboratory in cancer of the rectum, namely, the 

 marked enlargement of the intestinal glands 3 or 4 inches away from the 

 tumor. This phenomenon is visible on as many as six of my plants. I have 

 had sections made of one of these enlarged glands and they are now in 

 the process of staining, but not yet ready for study. 



I feel confident that I shall be able before very long to show on plants 

 by the use of this one microorganism {Bacterium tutnefaciens) all the 

 leading types of cancer as it occurs in man, exclusive, of course, of Glio- 

 mata and the like. 



Please show this letter to the good Doctors Mayo, and give them my 

 kindest regards. 



"43(1106): 348, March 10, 1916. 



''March 11, 1916, p. 833. 



"^^ Studies on the crown gall of plants etc., op. c'lt. (March 5, rec. for pub.). 



^^ Proc. Nat'l Acad. Set. 2: 444-448, Aug. 1916. 



"^ Letter, E. F. Smith to Thaxter, April 20, 1916. 



