Last Work. Tinai. Honors 603 



all dissolved into a brown debris and around this there is formed a thin 

 fibrous wall. In this stai;e it is impossible to kill guinea pi^s by injecting 

 bits ot these parts of the worm previously containing enormous cjuantities 

 of a very virulent culture. All arc dead. 



The Bi(L'fen/ffff ///me fac/ens experiments liad produced no tumors. 

 " Those larvae kept at 37^C," Smith was told, '" were not injured 

 by the or_ganism; those kept at room temperature (20''C) were 

 killed." His journal memoranda read: 



He used very larye doses, too many organisms I think. [September 18] 

 In smears made from worms injected with Bacf. lumejaciens four hours 

 previously, the rods are capsulatc and very short and in smears made after 

 48 hours the rods are larger and inclined to be in chains and non-capsulatc 

 and the worms are killed, if kept at room temperature. M. thinks a new 

 strain- has been developed. I am in doubt. He has not tried out the " new 

 strain " on any plants. 



Director Roux was " most cordial " to Smith. On the second 

 day of his visits, he had an hour with the famous French physician, 

 bacteriologist, pathologist, pupil of Duclaux, collaborator with 

 Pasteur and Chamberland, and whom he had heard believed cancer 

 of parasitic origin. When Smith showed him his crown gall photo- 

 graphs, he sent for Dr. Calmette; and they both " asked many 

 questions and showed great interest." In the Director's office, 

 he met Dr. Rcgaud, said by Besredka to be " the most expert 

 radiologist in France," and " famous for his studies of mito- 

 chondria in animal cells." ^' Later, at the Madame Curie radium 

 laboratories in Paris, Professor Rcgaud and his associates w'ould 

 show Smith " many interesting things, including numerous photo- 

 graphs of remarkable cures effected, some by X-ray, others by 

 radium." In 1923, at a clinic of the New York State Institute 

 for Study of Malignant Disease, he had learned of " similar 

 encouraging results " from treatments by x-ray for special types 

 of cancer. On this European journey Smith was truly the president 

 of the American Association for Cancer Research and would study 

 the subject from the standpoints of diagnosis, treatment, pallia- 

 tives, biology, and etiology. '- 



On September 23 he began to divide his visits between the 

 Pasteur Institute and the Laboratory of Plant Pathology, number 



^^ Some newer aspects of cancer research, Science 61(1589): 596, June 12, 1925. 

 ^^Idem, 595-601. 



