Last Work. Final Honors 619 



with FricJlarulcr, Ma<;nus, and other eminent pathologists. She 

 had "been working on tumors in this Laboratory since 1918, 

 definitely on human and animal tumors due to bacteria since May, 

 1923." Hers was the discovery of the bacteria in the breast 

 cancer, PM, so-called because of her initials. She had inoculated 

 the sunflowers and obtained the results about which Smith had 

 read in Paris. At once she showed Smith a diagram of her 

 experimental plots. He saw on 



one plot she inoculated B^tct. tmnejacieus. On the other plot, separated by 

 a roadway (width 3 to 4 feet) she inoculated PM. and obtained many 

 tumors on sunflaivcrs and tomatoes. She is quite certain there was no 

 '" verwechelung " of the cultures or cross-inoculations. Dr. Blumenthal has 

 given me photographs of three PM tumors on plants (All on sunflowers. 

 The one on cactus is due to Bacteriuiu tumefaciois) . I also saw many rats 

 inoculated \yith PM. 1 2th transplant, also transplants of Hu tumors as big 

 almost as English walnuts and several with good metastatases. I saw also 

 histological preparations of the animal grafts (sarcomas and carcinomas). 

 Dr. Blumenthal assured me that they held controls, i. e. animals inoculated 

 only with cancer serum and kiesclgur and with these two they were not 

 able to cause tumors. I also saw stained sections of a mouse tumor said 

 to have been produced without addition of either Kieselgur or cancer 

 serum. It contained epithelial pearls and appeared to be a beginning skin 

 cancer. ... I examined stained slides of the bacteria from PM, Be, Ze, 

 Hu(2nd) and Rhode and one other. They all look much like Bacterium 

 tumefacie72S. All were well stained and sharp. They arc short rods single 

 or paired. Fuchsin stain, I think. I saw also some of the sunflowers first 

 inoculated with PM (out of doors on large plants). The tumors were as 

 large and as typical looking as any we have obtained in Washington with 

 Bact. tu77iejaciens. Dr. Auler is now trying to grow Bad. tumefaciens in 

 cancer serum at blood temperature and if he succeeds he will then inoculate 

 animals with it. The one strain they now have came from Jensen in Copen- 

 hagen, it is said. It our hop strain, I think. 



Smith inspected the cancer clinic, and was told of vaccines being 

 used to relieve extreme suffering. These vaccines were experi- 

 mental and in some cases improvements had taken place. Dr. 

 Auler, among other things, was trying " histidin." He later went 

 through the main building and another known as the Polyclinic. 

 Various doctors accompanied him, and on the first evening Dr. 

 Blumenthal took him to a meeting of the Berliner Medicinische 

 Gesellschaft held in the Hygienic Laboratory. Three hundred of 

 the two thousand members were present, and Dr. Kraus, the 

 organization's president, introduced Smith as their " distinguished 



