Last W'cirk. Tinai. Honors 625 



he read on the train. Dr. Warburg had been "' very pleasant and 

 expressed great interest in [Smith's] crown gall studies.'" He 

 found Warburg's paper " exceedingly interesting," since it verihed 

 experimentally what Smith had thought out about " oxygen hunger 

 as the cause of cell division." *^'' 



On the afternoon of their first day in Copenhagen, Smith set 

 out to locate Dr. C. O. Jensen and, after arranging a future 

 appointment with Dr. Johannes Fibiger, found Dr. Jensen in the 

 Serum Laboratory of the Royal Veterinary and Agricultural High 

 School. Jensen asked to hear of the Blumenthal work, and Smith 

 showed him the ten slides which Miss Meyer had given him. One 

 slide the distinguislied Dane pronounced a sarcoma, another from 

 the same rat "possibly an endothelioma," but he said generally 

 of the slides he " had never seen any tumor like it." They dis- 

 cussed foot-and-mouth disease of cattle which recently had made 

 its way into Denmark and for which a serum had been prepared. 

 Smith met his son who was studying axolotls, North American 

 tailed amphibians. They showed him through the laboratories 

 and he promised to return later. 



The next day Smith had no special appointment. But he went 

 to Professor Albert Fischer, pathologist of the university insti- 

 tute for general pathology in connection with Rigs Hospital, 

 and spent two hours with him. In exchange for a promise to send 

 crown gall cultures and papers, Fischer gave Smith a set of his 

 publications. This became " another superb day." Fischer had 

 studied in New York and Smith saw some of his work. He 

 wrote,'"" 



He has been able to grow cells of Rous* chicken sarcoma in serum, something 

 Rous was not able to do, by adding to the drop a bit of muscle and a trace 

 of embryo juice to harden the scrum. The sarcoma cells invade the muscle, 

 destroy the protoplasm and liquefy the serum, something normal cells do 

 not do. \n this way he has by transfers every second day kept the chicken 

 tumor cells alive out of the body for two years. I saw such cultures under 

 the microscope. These two year old cultures when introduced into fowls 

 cause virulent tumors, some of which I saw. In the lungs of one such fowl, 

 there must be a thousand metastases. ... He tells me Dr. Alexis Carrel 

 is now studying cancer intensely in New York, and has found that he can 

 convert the big mononuclear leucocytes into tumor cell, by treating them 

 with the Berkcfeld filtrate from Rous' chicken sarcoma. Dr. Fischer intro- 

 duced me to his chief, Professor Dr. Thomsen, and together we went to an 



"'Journal, Mar. 10, 11, 12, 1924. ""Journal, Mar. 14, 1925. 



