626 Third European Journey 



amphitheatre where they had a lantern operator throw upon the screen a 

 series of interesting slides of tissue cultures of normal fibroblasts and 

 epithelial cells which behave quite differently, the former never changing 

 into the latter and when cultivated together the normal epithelial cells grow 

 as gland-like nests in the midst of the fibroblasts. He also showed slides 

 of the chicken sarcoma cells invading small pieces of muscle. ^^^ 



That afternoon Smith tried to consult " the great surgeon Dr. 

 Rovsing, almost," he believed, " the only man in Copenhagen who 

 has insisted that cancer must be due to a parasite." The Doctor 

 was ill, but he enjoyed meeting his son Christian, first assistant 

 surgeon, and Dr. Rovsing senior wrote Smith cordial letters after 

 his return to America. 



Professor Fibiger called on Dr. and Mrs. Smith late that after- 

 noon, and Dr. Fischer requested that he and other doctors of his 

 laboratory be shown the Blumenthal rat-tumor slides and crown 

 gall photographs. Accordingly, two days later,^^® Smith went to 

 Fischer's laboratory in the morning and to Dr. Jensen's laboratory 

 in the afternoon. He showed his photographs and ten slides of the 

 rat-tumors; four sunflower PAi tumors; and three whole rats, one 

 inoculated with PAI and two with L. Dr. Thomsen, a bacteriolo- 

 gist Dr. Jensen, and a young doctor were also present at the 

 morning conference. Dr. Fibiger, at his " patologisk-anatomiske " 

 laboratory on March 17, saw these materials, or most of them, 

 during a two-hours' interview with Smith. He inquired whether 

 either Dr. Jensen or Professor Thomsen planned to " repeat " the 

 experiments. He wished to do so, and for the purpose arranged 

 with Smith to send him cultures of " all the strains " of Bacterium 

 tumejaciens his laboratory had. Fibiger thought that the slides of 

 the L inoculations indicated " malignancy more than do those of 

 Py\l." He promised to send " a series of his cancer slides " and 

 told Smith some points from his own work which prompted the 

 latter to conclude that, perhaps, what " Blumenthal has observed 

 in his rat-tumors occurs also ... in tar-cancer of mice." Smith 

 wrote in his journal: 



In mice attacked by cancer due to tar-paintings he said he got both sar- 

 coma and carcinoma, and mixed carcino-sarcoma in the same animal, and 

 this he demonstrated to me in well-stained preparations. In one and the 

 same mouse I saw (1) good invasive carcinoma in the muscles, (2) in the 



^^'' See, Some newer aspects of cancer research, op. cit., 598. 

 "* Journal, Mar. 16, 1925. 



