628 Third European Journey 



gen. Slides of Deelman's " very early stages of tar cancer in mice " 

 were, nevertheless, at the Leeuwenhoek Huis, and he studied these 

 on March 24, finding that they showed what Deelman " claimed, 

 i. e. appositional growth in early stages of the tumor." ^-^ Of the 

 Blumenthal " schizomycete isolated from human breast cancer," 

 Smith wrote Miss Hedges of his laboratory.^" " I have come to the 

 conclusion that they have isolated something . . . that will produce 

 tumors in rats and crown galls in plants — either bacteria (the 

 visible thing) or some invisible virus carried over along with 

 the bacteria must cause the rat tumors." He was meeting " the 

 cancer specialists of Amsterdam " — Dr. Bonne, Dr. W. F. Was- 

 sink, Dr. W. M. de Vries, and Dr. Nicolas Waterman, among 

 others. Dr. Wassink told him of " remarkably successful " cancer 

 treatments by radium and x-ray. He discussed with Dr. Bonne some 

 questions about parasites ^"^ believed found in tar-treated mice. 

 He showed these doctors his crown gall photographs and Blum- 

 enthal rat-materials,^-'* and then he and Dr. Waterman, a biologist, 

 may have discussed Dr. Otto Warburg's work.'^-^ Smith told his 

 first American audience that Waterman had " verified Warburg's 

 results obtained on rats, /'. e., the glycolytic action of cancerous 

 tissue on grape sugar with production of a great excess of lactic 

 acid, using, in vitro, a variety of human cancers ... I suspect," 

 he said, " as does also Waterman, that small quantities of other 

 acids may be present and act as stimulants to cell-division." 



On March 23 Professor Johanna Westerdijk of the Centraal- 

 Bureau voor Schimmelcultures at Baarn telephoned and sent a 

 letter to Dr. Smith: 



I am so glad to see you here to-morrow, both of you! I do not know 

 what other plans you have in Holland, but on Friday from four to five 

 I have my university lecture in Utrecht. I should care very much that all 

 my students at Utrecht should meet you and hear you. I wonder whether 

 you (instead of myself) would care to give them that lecture. Utrecht is a 

 nice old town, where I might show you things. Please think of it. I was 

 just going to treat " Vegetable galls " in my lecture; think of just having 

 you here at the time ! 



Dr. and Mrs. Smith went to Baarn and were taken by Miss 



'"Journal, Mar. 24, 1925. 



'" Letter written at Baarn, Mar. 26, 1925. 



123 



See, Recent cancer research, op. cit., 243. 

 '^'^ Journal, Mar. 24, 1925. 

 ^"^ See, Some newer aspects of cancer research, op. cit., 597. 



