544 Crown Gall-Animal Cancer Analogy 



not go to North Carolina that year. We do not know definitely 

 what research plans he had in mind, but, as an extension of his 

 study of chemically induced crown galls, he perhaps wanted to 

 investigate chemically induced growth in unfertilized eggs of 

 animals. He had read and written of Dr. Jacques Loeb's study of 

 compounds which start growth in unfertilized eggs of the sea 

 urchin. '^° This had definite significance, he thought, in his study 

 of the chemical excretions of Bacterium tumefaciens. 



Yet before him was the task of finally completing for publica 

 tion his paper on "Appositional Growth in Crown Gall and in 

 Cancer." As early as January he had finished a final reading of 

 this and begun to seek a publisher. Three or four figures in the 

 text and many photomicrographs were to illustrate it. In March 

 he was invited to address the cancer research association, and his 

 address became a condensed version, or abstract, of the paper. 

 Still, he was in doubt about some points of medical pathology. 

 So he began a journey to more cancer research centers. 



He first v/ent to Philadelphia and consulted with Dr. True of 

 the department of botany at the University of Pennsylvania. He 

 read all of one day in the medical library and then v/ent on to 

 New York. 



Five days were spent in New York consulting with cancer 

 research specialists at the Crocker Institute of Columbia Uni- 

 versity and at several laboratories of Cornell University Medical 

 College. Extracts from his diary May 22-May 25 reveal the im- 

 portant research work he found being performed there: At the 

 Crocker Institute he 



met Mr. Kegerreis and saw 200,000 volt x-ray machine and Dr. Woglom 

 showed me around. I was most interested in the new Sarcoma of white 

 rats produced in six months to eighteen months by feeding Cysticercus eggs 

 from cat's dung. Some strains of rats are more susceptible than others and 

 young rats than old ones, in fact old rats are free from liver cysts due to 

 the worm. Not all of the rats develop the Sarcoma by so far [as] 4% 

 to 36% and not all cysts in the same rat show it. It is a malignant disease 

 metastasizing freely. I saw one rat dissected (dead at end of 18 months) 

 and many in formalin. They have over 5000 inoculated. They feed the 

 eggs by washing them out with water strained through cloth. . . . They 

 have promised me a set of slides. 



'"Chemically induced crown galls, op. at., 313; Mechanism of overgrowth in 

 crown gall, op. at., 439-440. 



