FURTHl-R Ri;Sl-ARCHi:S IN DiSliASl-S Ol F'lants 545 



May 2S: Spent most of the day with l)rs. Stoi.kard and CJianibcrs at 

 Cornell Medical SJiool and worked on Chambers papers and ms [ Apposi- 

 tional Growth in Crown Gall and in Cancer] till 9 p. m. 1 !e is to teach me 

 how to manipulate his improved I^arber apparatus. I wish to use it to inject 

 cells with crownuall bacteria and watch their behavior under the micro- 

 scope. I had my first lesson today. 



May 24: All day at Cornell Medical School. . . . Talked with Charles 

 Stockard. Talked and lunched with James Ewing and worked all afternoon 

 in Chambers' Laboratory. He has made substantial improvements in 

 Barber's apparatus and I am learning how to use it. 



May 25: At the Crocker Laboratory. . . . Saw Dr. R[ohdenburg] feed 

 Norwegian rats with cockroaches infested with Fibiger's Gonglyonema 

 nematodes. Later saw eggs and cysts and a worm escape from a cyst after 

 repeated trials. Dr. R. also showed me slides showing stomach and tongue 

 carcinoma due to the nematode. 



The slides. Smith believed, were Fibiger's. 



Spiroptera neoplastica is the scientific name now applied to the 

 Dane Johannes Fibiger's carcinogenic worm, Gong)lonemci neo- 

 plasticnw. This, and Cysticercus fascioiarus (the larval form of 

 a cat tapeworm. Taenia crassicollis), are malignant tiimor-inducing 

 agents in animals,''' and Smith, in his study of Bacterium tume- 

 facieus, had been investigating what he believed to be a malignant 

 tumor-inducing agent in plants. He was familiar with Borrel's 

 position which, to quote Oberling,*"' was that " neither the Spirop- 

 tera nor any other parasite can provoke a malignant tumor unless 

 contaminated with a carcinogenic virus." His diary comments, 

 however, made no reference to Borrel's hypothesis, whatever more 

 he was to say on this subject later that year in his address before 

 the Radiological Society of North America on " Twentieth Cen- 

 tury Advances in Cancer Research." '^^ 



On May 25 Smith observed Miss M. R. Curtis of the Crocker 

 laboratory dissect two rats fed with Taenia eggs from cat feces. 

 Borrel had seen and attempted artificial infestation to study the 

 rat-liver cyst sarcoma. But, his work having been interrupted,"* 

 the further work of Bullock and Curtis became very important. 

 Smith wrote into his diary a memorandum on the dissections, 

 believed it " undoubtedly sarcoma and tremendously interesting," 



" Chas. Oberling, The riddle of cancer, op. cit., 67, 69. 

 «' Idem, 70. 



"0/7. cit.. Worm cancers, 303-311. 



'* Oberling, op. cit., 73; Smith, Twentieth century advances in cancer research, 

 op. cit., 309. 



