ri'inni K Ri si:ar{ urs in Disi;asi;s oi- Plants 575 



at this moment I possess only a very restricted number of good stained slides 

 showini; the nem.itode-i.ari.inoma, but I think I may be able to ^ive you 

 some good photos, and 1 shall send these as soon as they have been finished. 

 If, in the next time, I should get some beautiful specimens, I shall send 

 them to you. . . . 



Smith in 192i sent hun a copy of his address and called his 

 attention to the fact that he had given " a good deal of space to 

 your beautiful researches which I considered to have advanced 

 cancer research very materially. 1 mounted up the photographs 

 which you sent me on a big sheet and exhibited those also at the 

 X-ray Congress." "Fibiger became president of the committee for 

 cancer research in his country and, as such, was congratulated by 

 Smith who by that time was president of the American Association 

 for Cancer Research. He cordially responded on behalf of the 

 Danish Association and the cancerologists of his native land. A 

 year or so thereafter, he, because of his discovery of the Spiroptera 

 carcinoma, won the Nobel prize in physiology and medicine. 



While preparing his address, Smith had abundantly read the 

 literature of many cancer research workers — Rous, Fibiger, Kopsch, 

 Borrel, Haaland, and others. Both his text and his diaries show 

 this, and included among them were works from students of 

 experimental coal tar cancers. Early in 1923 Koitchi Itchikawa 

 sent him from Japan " a whole bundle of cancer papers." Further- 

 more, in 1925, he was to meet Dr. Itchikawa in Dr. G. Roussy's 

 laboratory at the Ecole de Medicin of Paris and be given by him 

 eight more reprints on tar cancer. Smith outlined the earlier work 

 in his address. Dr. Katsusaburo Yamagiwa, erstwhile student of 

 Virchow, founder of the Japanese cancer journal, and professor of 

 pathology at the University of Tokyo, and Itchikawa, doctor of 

 veterinary medicine and also of the Tokyo pathological institute, 

 chose rabbits as their experimental animals and, on the theory 

 that rabbits' ears are peculiarly free from any suggestion of car- 

 cinoma growths, they painted their inner or outer surface every 

 second or third day more or less for a year with the coal tar itself 

 until at last papillomas and a few keratinizing carcinomas of a 

 mild type resulted. Other experiments with mice follov^'ed, per- 

 formed by Dr. Hidejiro Tsutsui, professor of general pathology 

 and pathological anatomy in the medical high school in Chiba. 

 Menetrier and Surmont in Paris confirmed K. Yamagiwa's and 



