650 Third European Journey 



ment of embryology of the Carnegie Institution of Washington, 

 Dr. Burrows of the Barnard Free Skin and Cancer Hospital of St. 

 Louis, and perhaps others. Each one denied the true neoplastic 

 nature of the tumor. After February of that year nothing further 

 on this subject appeared in any of Dr. Smith's writing or memo- 

 randa of his diary. Late in 1926 and early 1927, furthermore, 

 he gave much time to studying the so-called " cancer germ " and 

 method of treating cancers by antitoxin of Dr. T. J. Glover of 

 New York City. Dr. William B. Coley arranged on November 

 16 ^'"^ for his first appointment with Dr. Glover who had been 

 seven years at work on his antitoxin and had never sold it or 

 made money with its use. Dr. Glover showed him young and old 

 cultures of his organism, his collection of tumor-bearing animals, 

 stained sections of various types of cancers, explained his work, 

 and gave Smith cultures of his organism to study in his laboratory 

 at Washington. Dr. Smith spent parts of three months studying 

 the " schizomycete," ^'^ and his conclusions,^'* some of which were 

 suggested, found, or verified by Dr. Thom, were that the organism 

 was not a " schizomycete," as Dr. Glover had told him he believed, 

 but contained several organisms. Smith wrote: " I have found one 

 ' spore sack,' that of Glover's ' cancer germ,' to be the conidia of 

 Penicillium brevicaule, a contaminating fungus. The rest of the 

 ' germ ' was made up of several types of sporulating bacteria." 

 On March 1, 1927, Dr. Woglom acknowledged receiving from 

 Smith a paper entitled, " Glover's ' cancer germ,' " to be read at 

 the Rochester meeting of the American Association for Cancer 

 Research. This paper was never presented, and for reasons soon 

 to be disclosed. 



Practically all of Dr. Smith's last publications had been based 

 directly upon, or built around, his work in crown gall. He had 

 continued to direct and supervise all of the work of his laboratory. 

 Much important work had been done by his co-workers. Miss 

 Hedges' study of the bean disease {Bacterhmi fiaccumfaciens) 

 had been extended to Europe and it was known that its cause is 

 transmitted " from year to year on and in the seeds." In 1923- 



^^ Diary, Nov. 16, 1926; interview with Dr. Glover, Nov. 17; interviews with 

 other New York doctors concerning Dr. Glover's work, Nov. 18-19. 



"' Diary, Dec. 20, 21, 22, 23, 24, 28, 1926; work continued. Diary, Jan. 14, 1927; 

 conference with Dr. Thom, Diary, Feb. 7, 1927. 



^■'^ Fifty years of pathology, op. cit., 35. 



