because it does not consider the cell cycle at all. One chapter 

 deals with the hormonal regulation of proliferation and differ- 

 entiation. A question considered by several contributors is 

 whether the cell's environment alone triggers cell differentia- 

 tion, or whether internal "temporal genes" are Involved. 



52. 



CD. R.DUNN. 1971. THE DIFFERENTIATION OF HAEMOPOIETIC STEM CELLS 

 Munksgaard, Copenhagen. Series Haematologica Vol.4, nr.4, 71 pp., 

 12 figs. D.Kr.50.00, £ 3.08 (paper) 



Review emphasizing the normal differentiation of stem cells, 

 the role of the micro-environment, and the influence of more than 

 10 different agents and treatments on differentiation; colony- 

 forming cells from bone marrow developing in the spleen and in 

 vitro, respectively, are considered and the results compared. 



M.DVO'J^AK. 1971. SUBMICROSCOPIC CYTODIFFERENTIATION 

 Springer, Berlin, etc. Ergebn. Anat .Entw.gesch. Bd.45, H.4. 

 118 pp., 48 figs., 3 tabs., subject index. DM 50.00, $ 15.60 



Extensive descriptions, based on original research, of sub- 

 microscopic differentiation of 1) rat ovum during cleavage, 

 2) liver cell, 3) pancreas exocrine cell, and 4) erythrocyte; 

 emphasis on nucleus and cytoplasm, much less on cell membrane; 

 comparison with literature data; separate chapter on origin of 

 cell organelles; good original electron micrographs. 



54. 



A.HERVONEN. 1971. DEVELOPMENT OP CATECHOLAMINE-STORING CELLS IN 



HUMAN FETAL PARAGANGLIA AND ADRENAL MEDULLA, a histochemical and 



electron microscopical study 



Acta Physiol. Scand. , Suppl.368. 94 pp., 64 figs., 2 tabs. 



Fetuses aged 6-27 weeks; formaldehyde-induced fluorescence; 

 cholinesterases ; vascular supply of paraganglia and adrenal me- 

 dulla; electron microscopy; disc-ussion of possible humoral in- 

 duction of differentiation, and of possible endocrine function 

 of chromaffin cells. 



55. 



J.KARTENBECK, H.ZENTGRAF, U.SCHEER, W.W.FRANKE. 1971. THE 



NUCLEAR ENVELOPE IN FREEZE-ETCHING 



Springer, Berlin, etc. Ergebn. Anat .Entw.gesch. Bd.45, H.l. 



55 pp., 45 figs., 2 tabs., subject index 



A brief section deals with the amphibian oocyte nucleus: ex- 

 cellent illustrations; extensive bibliography. 



56. 



D.METCALF and M.A. S.MOORE. 1971. HAEMOPOIETIC CELLS 

 North-Holland, Amsterdam; Am, Elsevier, New York. Frontiers of 

 Biology Vol.24. XIV, 550 pp., 124 figs., 31 tabs., subject index. 

 D.fl.120.00, ca.$ 35.25 



Contents: 1. General description of blood cells and haemopo- 

 ietic organs; 2. Techniques in experimental haematology and 

 their limitations; 3. Haemopoietic stem cells and progenitor 

 cells; 4, Embryonic aspects of haemopoiesis; 5. Haemopoietic 

 cell migration streams in adult life; 6. Microenvironmental 

 regulation of haemopoiesis; 7. Humoral regulation of haemopo- 

 iesis; 8. Senescence of haemopoietic tissues; 9. Neoplasia of 



32 



