by means of rontgen cinematography. All contributions have extensive bibliographies, that of 

 the first one consisting of more than 250 titles. 



The book is well printed and beautifully illustrated; many of the photographs are rontgen 

 cinematographs. 



Teratogenesis (see also 22, 26, 28, 52, 57, 58, 60, 77) 



Monographs 



32 



RECOGNIZABLE PATTERNS OF HUMAN MALFORMATION, genetic, embryologic, and clinical 



aspects. 1970. By D. W. SMITH 



W. B. Saunders, Philadelphia. Major Problems in Clinical Pediatrics, vol. 7. 383 pp., 618 figs., 



subject index. $ 16.00, £ 6. 16 s. d. 



This book is of almost exclusive interest to pediatricians. The reason why it is reviewed 

 here is that, apart from the main subject matter, it contains a separate chapter devoted to 

 normal morphogenesis. 



The first two chapters of the book are entitled "Single syndromic malformations resulting 

 in secondary defects" (17 pp.) and "Dysmorphic syndromes of multiple primary defects" (277 

 pp.). The first chapter contains diagrams of the hypothetical embryonic origins of the malform- 

 ations in question. Chapter two contains a virtually complete listing of all syndromes known 

 up till 1968, and a set of summary tables which are meant to assist the clinician in differential 

 diagnosis. 



Chapter three is entitled "Morphogenesis" (28 pp.) and begins with a summary view of 

 overall human embryonic and fetal development. Then follow sections illustrating aspects of 

 the morphogenesis of the eye and lens, the kidney, the limbs, the thyroid, and the pituitary. 

 The chapter is concluded by a table listing the embryonic processes affected and the latest 

 possible time of causation of some malformations that represent incomplete stages in morpho- 

 genesis. The book is concluded by chapters on genetics and genetic counseling, and on minor 

 malformations. 



The book is well printed and is profusely illustrated, mainly with photographs. In chapter 

 three these are mostly micrographs of reasonable but not excellent quality. On the cover- 

 papers there appears a useful chart of the chronology of normal human development. 

 References are interspersed throughout the text. 



Dissertations 



33 



THE NORMAL PALATE AND INDUCED CLEFT PALATE IN RAT EMBRYOS, an in vivo, in 

 vitro and autoradiographic study on embryological development. 1969. By R. NANDA 

 M.D. thesis, Nijmegen. 120 pp., 65 figs., 13 tabs. 



Normal development of secondary palate; teratogenic effects of vitamin A and Dexameth- 

 asone explants from normal and drug-treated mothers; explants treated with drugs in vitro; 

 autoradiography using 35 S and 3 H. 



Symposium reports 

 34 



CONGENITAL MALFORMATIONS. 1970. Edited by F. C. FRASER and V. A. McKUSICK, Co- 

 Editor R. ROBINSON 



Excerpta Medica, Amsterdam. International Congress Series No. 204, 466 pp., 141 figs., 97 

 tabs., author and subject indexes. ISBN 90 219 0135 8. $ 27.50, £ 11.10.0 



Contributors: Abercrombie, Aladjem, Apgar, Barnes, Berendes, Brent, Burns, Carter, 

 Church, Clarke, Dawid, Ferguson-Smith, Gellis, German, Hauge, Hay, Hess, Hillman, Jacobs, 

 Kirkman, Langman, Lenz, Lilienfeld, Lind, Littlefield, McKusick, Markert, Maroteaux, Menkes, 

 Miller, Morton, Motulsky, Nishimura, Papaconstantinou, Polani, Robbins, Schimke, Sever, 

 Siniscalco, Smith, Stern, Taylor, Ursprung, Warkany, Weiss, Whittingham, Wilson, Witschi, 

 Yerushalmy 



This magnificently produced book contains the proceedings of the Third International 

 Conference on Congenital Malformations held in the Hague, Netherlands, 7-13 September, 



337 



