Dissertations 

 40 



CELTRANSFORMATIE BIJ REGENERATE, een experimenteel onderzoek bij axolotl-larven (Cell 



transformation during regeneration; an experimental investigation on axolotl larvae), 1971. By 



A. E. HARREBOMEE 



M.D. thesis, Amsterdam. 2 vols. English summary (3 pp.) 



vol. I text. 72 pp., 6 schemes 



vol. II 11 plates 



Transplantation of limb cartilage, muscle, or dermis to the flank, covered by limb wound 

 epidermis; dedifferentiation, blastema formation, and development of incomplete limbs; his- 

 tological evidence of cellular metaplasia. 



Symposium reports 



41 



REPAIR AND REGENERATION, the scientific basis for surgical practice. 1969. Edited by J. E. 



DUNPHY and W. VAN WINKLE, Jr. 



McGraw-Hill, New York. 378 pp., 169 figs., 26 tabs., 4 pis., combined index to subjects and 



contributors. $ 29.50 



This book contains the papers presented at a Symposium held in San Francisco in February 

 1968. There were 26 participants from the U.S.A. and Great Britain, belonging to a wide 

 variety of disciplines. The emphasis was on the applicability of results to clinical medicine and 

 surgery. Nevertheless, many of the new data reported will be of interest to experimental 

 biologists working on wound healing and repair, particularly in mammals. 



The 24 papers are arranged in six sections as follows: I Inflammation and immunity (3 

 papers); II Skin repair (5); III Connective tissue repair (5); IV Wound remodelling (2); V 

 Biological factors in wound healing (3); VI Practical and clinical aspects of repair (6). The 

 discussions held at the Symposium are not recorded. 



Contributions worth special mention are a paper by Bullough on epithelial repair, and one 

 on epithelio-mesenchymal relations by Grobstein (section II); a paper on collagen biosynthesis 

 by Rosenbloom and Prockop, and one on mucopolysaccharide synthesis by Peter (section III); 

 a paper on enzyme induction and growth control by Argyris, one on nutritional and environ- 

 mental aspects of wound healing by Hunt and Zederfeldt, and a long paper by Urist on 

 inductive substrates in new bone formation (section V). 



The book is well printed and well illustrated. It has no author index. 



42 



REGENERATION OF STRIATED MUSCLE, AND MYOGENESIS. 1970. Edited by A. MAURO, 



S. A. SHAFIQ and A. T. MILHORAT 



Excerpta Medica, Amsterdam. International Congress Series, no. 218. 309 pp., 229 figs., 12 



tabs., subject index. ISBN 90 219 0142 0. $ 20.—, £ 8.35, H.fl. 72.— 



This book embodies the proceedings of an international conference convened by the Muscu- 

 lar Dystrophy Associations of America, and held in New York in March 1969. The conference 

 was attended by 33 scientists, one third of whom came from outside the U.S.A. Most partici- 

 pants were anatomists, biologists, and pathologists. 



Most of the 22 contributions are not formal papers but spontaneous presentations interspersed 

 with questions from the audience and other discussion matter. Frequently these discussions 

 are quite extensive and have their own illustrative material and literature references. Some of 

 the papers are so distended by discussions that they become very difficult to read. Moreover, 

 they lack summaries, which could partly make up for this. 



The studies reported relate to muscle regeneration and myogenesis (both normal and 

 abnormal, both in vivo and in vitro) in a variety of amphibians and mammals (including man). 

 The techniques used are restricted almost entirely to light and electron microscopy, sometimes 

 combined with isotopic labelling. A considerable amount of discussion centres around the 

 satellite cell concept. J. H. Venable has provided a brief but critical summary of the conference 

 which shows, not surprisingly, that it raised more problems than it solved. 



The book is well printed and illustrated with numerous good photographs and electron 



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