extensively here; as a partial substitute the complete table of contents is printed above. This 

 will show the extraordinarily broad scope of the book; this, together with the unquestionable 

 high standard of authorship, ensures that the book will become a classic in its field. We can- 

 not but feel grateful to the editors and authors for the tremendous amount of work and 

 thought that has gone into it. 



One general feature of the book may be mentioned: the authors were asked to organize 

 their material according to their personal perspectives or biases, and not to avoid far-reaching 

 interpretations and concepts. Even though some of these may later turn out to be wrong, in 

 the present state of flux in which this field finds itself they serve the purpose of stimulating 

 discussion, thought, and further experimentation. 



The book is beautifully illustrated and produced with the utmost care. All chapters have 

 extensive bibliographies. Some of these are up-to-date until 1968, others until 1967 or 1966. 

 The book has a rather brief subject index; the absence of an author index is regrettable but 

 perhaps excusable in view of the inevitable delay its composition would have caused. 



Monographs 



68 



NUCLEUS AND CYTOPLASM. Second edition. 1970. By H. HARRIS 



Clarendon Press, Oxford. 199 pp., 16 figs., 18 pis., 1 tab., author and subject index. SBN 



19 854113 9. $ 8.75, £ 1.90 (cloth), $ 3.75, £ 0.90 (paper) 



The first edition of this important and stimulating book appeared in 1968 and was reviewed 

 in "General Embryological Information Service", Suppl. 12, 1968, p. 13. The interest which it 

 met, and the rapid advances made in the last few years, fully justify the present enlarged 

 edition. Much new material has been incorporated, but the author has seen no reason for a 

 fundamental revision of his main conclusions, which entail much emphasis on the cytoplasmic 

 rather than nuclear control of protein synthesis. 



The organization of the subject matter has remained unaltered, but the following new sec- 

 tions have been added: ch.2 ("The genetic operator model"): a section on negative control, 

 the operon, and the repressor; ch. 3 ("The search for the messenger"): a section on '45S' RNA; 

 ch. 4 ("Regulation"): a section on regulation by enzyme degradation; ch. 6 ("Differentiation"): 

 a section on stimuli for differentiation. In ch. 5 (now called "Cell fusion") the section on the 

 transfer of information from nucleus tot cytoplasm has been greatly expanded. 



Many of the original photographs have been replaced by newer ones. The chapter biblio- 

 graphies contain about 50% more titles, even though many of the original references were 

 eliminated. 



69 



CELLULAR MECHANISMS OF CHROMOSOME DISTRIBUTION. 1970. By P. LUYKX 

 Academic Press, New York. International Review of Cytology, suppl. 2. 180 pp., 21 figs., 8 tabs., 

 author and subject index. 



A general, comprehensive theory of chromosome movement in cell division is provided; 

 chapter I briefly reviews evidence suggesting that a precisely determined chromosome com- 

 plement is a prerequisite for cell reproduction and development. 



Dissertations 



70 



MORPHOLOGISCHE ANALYSE VAN DE EERSTE CELDELING VAN HET EI VAN LYMNAEA 



STAGNALIS L., een electronenmicroscopisch onderzoek, (Morphological analysis of the first 



cleavage of the egg of Lymnaea stagnalis L., an electron-microscopical investigation). 1971. By 



W. BERENDSEN 



Ph.D. thesis, Utrecht, 2 vols. English summary (2 pp.) ^v 



vol. 1 text (mimeographed). 110 pp., 16 figs., 7 tabs. 



vol. 2 illustrations. 92 electron micrographs 



Electron-microscopical study of fertilized egg and first cleavage division; formation of mid- 

 body and blastocoel; discussion of mechanisms of cell division. 



349 



