Throughout the book the emphasis is mostly on anatomical description of 

 the nervous system and related structures. The possible mechanisms of action 

 of teratogens are extensively discussed only for hypervitaminosis A, trypan 

 blue, and ionizing radiation. 



The book is in two parts, each occupying about half its total size. Part 

 one, entitled "Experimentally induced malformations", starts with a brief but 

 concentrated chapter on principles and techniques of experimental mammalian 

 teratology. It proceeds with chapters discussing the effects of nutrient 

 deficiency, hypervitaminosis A, trypan blue, ionizing radiation, and mis- 

 cellaneous other teratogenic substances and procedures. Part two is entitled 

 "Spontaneous malformations" and, after a brief introduction, proceeds to 

 discuss separately the genetic and sporadic malformations of the central 

 nervous system found in 1 1 mammalian species, in non-human primates, and 

 in miscellaneous other species. 



The illustrations are restricted to 27 photographs, 26 of which are original 

 and apparently were not published earher. The list of references covers 

 nearly 100 pages (its typography is rather awkward). The book is well 

 produced, and is concluded by author and subject indexes. 



49 NERVOUS REGULATION OF INTESTINAL 



MOBILITY IN ONTOGENESIS 

 1968 

 By E. M. Kobakova Publishing House "Nauka" 



131 pp., 20 figs., 5 tbs. Leningrad 



(paper-bound) 



This monograph is written in Russian and is announced only briefly. The 

 author has been an active worker in this field at the Pavlov Institute of 

 Physiology for over twenty years. The book reports on experimental work 

 carried out mainly with dogs and rabbits. The bibliography covers 17 pages, 

 14 of which are devoted to Russian literature, both older and recent. 



50 EXPERIMENTELLE PRAENATAL-TOXIKOLOGIE 



1968 

 By Th. von Kreybig Editio Cantor KG 



212 pp., 76 figs., 47 tbs. Aulendorf i. Wiirtt. 



Price: DM 64.— 



With this monograph the author has intended to present the biological 

 and toxicological foundations of experimental prenatal toxicology in mammals, 

 in connection with his own experience in the field. It was not his intention 

 to review the literature exhaustively. The book contains much original thought 

 and will certainly be stimulating reading for any specialist working in this 

 field and in the related field of teratogenesis. 



The organization of the book is logical and clear. The introduction is 

 followed by a chapter discussing the embryological and developmental- 

 physiological foundations, with special sections devoted to the rat, the mouse, 

 and the guinea pig. The next chapter deals with general aspects of prenatal 

 toxicology, such as phase specificity, organotropic effects, dose-response 

 relationships, and the general course of teratogenic processes. Then follows 

 a chapter summarizing the data of special prenatal toxicology, in which the 

 treatment is according to the chemical nature of the compounds tested. The 

 book is concluded by a useful chapter on the methodology of animal 

 experiments. 



334 



