53 KLINIK UND PATHOLOGIE DER DYSMELIE 



Die Fehlbildungen an den oberen Extremitaten 

 bei der Thalidomid-Embryopathie 

 1969 

 By H.-G. Willert and H.-L. Henkel Springer-Verlag 



147 pp., 36 figs., 4 tbs. Berlin - Heidelberg - New York 



Price: DM 38.—; $ 9.50 



This very thorough monograph is based on clinical and X-ray findings 

 in 203 dysmelic children (with 324 malformed upper limbs in all) examined 

 in the orthopedic clinic of the University of Heidelberg. Although the book 

 is no doubt of primary importance to orthopedic surgeons, it contains much 

 that will be of value for teratologists and embryologists interested in limb 

 development. 



The material is rigorously classified, and a continuous "teratological series" 

 is established, within which certain groups of skeletal malformations can be 

 distinguished, which constitute a skeletal malformation pattern. This pattern 

 is compared with that previously obtained for the lower limb in similar 

 material. Next the pattern is discussed in relation to limb malformations 

 obtained in animal experiments, and their possible explanations in terms of 

 "competition" between, and local restitution of skeletal rudiments. Finally 

 it is shown that neither the limb malformation pattern itself nor its as- 

 sociation with other malformations is specific for thalidomide. 



The book is very well produced and illustrated. It has a 14-page biblio- 

 graphy and a subject index. 



54 NUCLEIC ACID METABOLISM. CELL 

 DIFFERENTIATION AND CANCER GROWTH 



1969 



Editors: E. V. Cowdry and S. Seno Pergamon Press 



483 pp., 240 figs.. 46 tbs., 10 pis. Oxford etc. 



Price: 160 s. 



Contributors: Amano (Tokyo), Braun (New York, N.Y.), Busch (Houston. Tex.), Fitzgerald 

 (Brooklyn, N.Y.), Hagiwara (Kyoto), Hamashima (Kyoto), Hanafusa (New York, N.Y.), 

 Hanaoka (Kyoto), Haruna (Urbana, 111.), Hori (Sapporo), Ishikawa (Kanazawa), Ishizaki 

 (Kyoto), Iwata (Tokushima), Izawa (Tokyo), Kameyama (Kanazawa), Kasten (Pasadena, 

 Calif.). Kato (Osaka), Kawakami (Fukuoka), Kimoto (Okayama), Kinosita (Duarte, Calif.), 

 Kuroda (Mishima), Marco (Milan), Mitsuhashi (Maebashi), Miura (Chiba), Miyahara 

 (Okayama), Morikawa (Kyoto), Naora (Tokyo), Okada (Kyoto), Seno (Okayama), Shira- 

 kawa (Kyoto), Spiegelmann (Urbana. 111.), Suyama (Kanazawa), Takeuchi (Toyonaka), 

 Terayama (Tokyo), Thorell (Stockholm), Valladares (Madrid), Wakisaka (Kyoto), R. Wa- 

 tanabe (Kanazawa), Y. Watanabe (Tokyo), M. Yamada (Tokyo), M. Yamada (Tokushima), 

 Yamamoto (Tokyo), Yanagita (Tokyo), Zeuthen (Copenhagen) 



This book embodies the proceedings of the Second International Symposium 

 for Cellular Chemistry, held in Ohtsu, Japan, in October 1966. It was attended 

 by more than 100 scientists, chiefly Japanese workers. Of the 44 contributors, 

 32 were from Japan, 8 from the U.S.A., and 4 from Europe. The long lapse 

 of time since the Symposium took place diminishes the topical value of the 

 book. On the other hand, some of the Japanese work would not have been 

 accessible without this publication. 



The 38 research papers are grouped into four groups, dealing respectively 

 with: (1) transcription; (2) RNA-protein syntheses and cell differentiation; 

 (3) cell multiplication and differentiation; and (4) control of cell growth, 

 cell transformation and cancer induction by virus. Only the second and third 

 sections contain papers that are of direct interest to developmental biologists. 

 Among these are papers by Kawakami et al. on primary induction in 



336 



